Which factor does NOT contribute to difficulties in controlling mice?

The factor that does not contribute to difficulties in controlling mice is their preference for daylight activity. Mice are primarily nocturnal creatures, meaning they are most active during the night. This behavior actually aids in their survival and makes them less exposed to potential predators and human intervention during those hours.

The other factors significantly impact control efforts. Mice have a high reproductive potential, allowing their populations to grow rapidly, thereby complicating eradication efforts. Their ability to squeeze through small openings further facilitates their entry into homes and buildings, making physical exclusion challenging. Additionally, the presence of multiple nests can create a situation where mice are dispersed throughout an area, making it harder to locate and control the entire population effectively.